Anti-inflammatory and Antioxidan, UV Protection and Anti-photoaging, extracted from Propolis

Caffeic Acid Phenethyl Ester (CAPE), a natural compound derived from propolis, exhibits a range of pharmacological properties beneficial for topical application

1. Anti-inflammatory and Antioxidant Properties: CAPE has been recognized for its anti-inflammatory and antioxidant effects. A study published in the International Journal of Oral Science demonstrated that CAPE protects against oxidative stress and dampens inflammation via the heme oxygenase 1 (HO1) pathway. This was observed in preclinical models where CAPE protected against ligature-induced periodontitis and systemic bone loss by cortisone, supporting bone defect healing. The study concluded that CAPE exerted its antioxidative effects through the Nrf2-mediated HO1 pathway and its anti-inflammatory effects through NF-κB, highlighting its potential in periodontal disease treatment[3].

2. UV Protection and Anti-photoaging: Another study, published in the International Journal of Molecular Sciences, investigated the effects of CAPE on UV-induced MMP-1 expression in human skin. Chronic sun exposure, which can lead to distinct histone acetylation changes in human skin, is associated with the aging process. CAPE was found to inhibit UV-induced MMP-1 expression by targeting histone acetyltransferases, suggesting its role in preventing the degradation of collagen and the extracellular matrix in the skin. This indicates CAPE's potential as a protective agent against UV-induced skin damage and photoaging[5].

These studies underscore CAPE's promising topical benefits, particularly its anti-inflammatory, antioxidant, and anti-photoaging properties, making it a valuable component in skincare formulations aimed at protecting and repairing the skin.

Citations:
[1] https://onlinelibrary.wiley.com/doi/10.1002/ptr.7707
[2] https://www.sciencedirect.com/science/article/pii/S1756464623002372
[3] https://www.nature.com/articles/s41368-018-0039-5
[4] https://www.sciencedirect.com/topics/medicine-and-dentistry/caffeic-acid-phenethyl-ester
[5] https://www.mdpi.com/1422-0067/20/12/3055

Usage: For all kinds of cosmetics

Mixing method: Mix in ethanol

Usage rate: 0.05-0.1%

Product characteristics: light colored powder

Solubility: Limited solubility in ethanol (about 1%)

Storage: For long-term storage Store in the refrigerator. Temperature between 4 °C -8 °C At least 24 months old

INCI Name : Caffeic Acid (Phenethyl Ester)